Neuronal Biophysics

We search for simple biophysical and mathematical laws that define the behavior of cells, and specifically of neurons. Our primary biophysical goal in our neurophysiological studies is to understand and measure the relation between neuronal activity and mechanical events..

Stray Field NMR

Osteoporosis is a disease in which the density and quality of bone are reduced, affecting mainly post-menopausal women.

For now, there is no easy method to monitor early changes in BMD (bone mineral density) to assess hormonal treatment efficacy in osteoporotic patients, as existing tools are not sensitive enough. The goal of our project is to develop a small, simple, affordable, MR-based table-top scanner to detect cellular changes in fat percentage in bone marrow as an early indicator of treatment efficacy.

The Scientific Basis:  Bone marrow adiposity in postmenopausal women increases with osteoporosis. Hormonal changes associated with the postmenopausal phase trigger the pathways that alter the differentiation of mesenchymal stem cells into adipocytes, disrupting the equilibrium between adipocyte and osteoblast differentiation. This process starts long before BMD changes are obvious.

Experiments performed in our group demonstrated that changes occurring in the bone marrow that are related to the onset of osteoporosis and to its treatment, can be detected by the use of a mobile stray field NMR.

Based on these findings, we are developing a dedicated mobile stray-field NMR device that will allow monitoring bone marrow adiposity.

Magnetic Exchange

Magnetic resonance imaging (MRI) is mostly performed on protons associated with freely moving water molecules, as they are highly abundant in biological tissues yielding high signals. Nonetheless, much signal information originates from the non-aqueous species in the tissue, such as proteins and lipids. We aim to implement a novel MRI technique that allows the acquisition of signal generated by the protons adjacent to the semi-solid components of the tissue and combine it with quantitation analysis to extract the volumetric fraction of proteins or lipids. The proposed MRI sequence, MEX (magnetization exchange), can provide an insight into the content of species with restricted motion. The MEX sequence is illustrated in the figure.

Fig1.png

Brain Tumor response assessment

Volumetric measurements of brain tumors are important for accurate diagnosis and follow-up. However in clinical setup manual segmentation of high grade gliomas (HGG) is usually inapplicable as it is highly challenging, time consuming and user dependent. The aim of this study was to implement a deep learning (DL) approach to automatic longitudinal assessment of brain tumor response based on the clinical response assessment in neuro-oncology (RANO) criteria.

Fig3.jpg